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Pros and Cons of Semaglutide for Weight Loss

Semaglutide for Weight Loss
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If you’re exploring new methods for managing your weight, you may have heard about semaglutide. Thanks to its ability to help patients lose weight and keep it off, the medication has become widely popular.

But like any drug, semaglutide comes with its own advantages and drawbacks. In this article, we’ll take a closer look at its pros and cons to help you decide whether it’s the right choice for you.

What Is Semaglutide and How Does it Work for Weight Loss?

Semaglutide is a glucagon-like peptide-1 (GLP-1) receptor agonist that was originally developed for the treatment of type 2 diabetes. It mimics a hormone in the body called GLP-1, which is involved in appetite regulation and insulin secretion.

By activating GLP-1 receptors in the brain, semaglutide reduces hunger and increases satiety, thereby helping users consume fewer calories. Additionally, semaglutide slows gastric emptying, meaning food stays in the stomach longer.

What Are the Pros of Semaglutide for Weight Loss?

Some of the numerous benefits of semaglutide for weight loss include:

  • Effectiveness: Clinical trials have demonstrated that semaglutide can lead to substantial weight loss, with many participants experiencing a body weight reduction of 15% or more.
  • Improved Metabolic Health: Beyond weight loss, semaglutide can improve various markers of metabolic health, including blood sugar levels, insulin sensitivity, and lipid profiles.
  • Sustained Results: Studies indicate that the weight loss achieved with semaglutide can be sustained over longer periods, unlike with many other weight loss interventions.
  • Convenience: Semaglutide is administered via a once-weekly injection, making it a convenient option for those who prefer not to take daily medications.
  • Better Cardiovascular Health: As an added benefit, semaglutide has been associated with a reduced risk of cardiovascular events such as heart attack and stroke.
Cons of Semaglutide

What Are the Cons of Semaglutide for Weight Loss?

While semaglutide is an effective tool for weight loss, it’s not without its drawbacks. These can include:

  • Side Effects: Common side effects include nausea, vomiting, diarrhea, and constipation, which can impact users’ quality of life.
  • Cost: Semaglutide can be expensive, and it’s not covered by most insurance plans unless used for type 2 diabetes, making it inaccessible for some patients.
  • Long-Term Safety: The long-term safety of semaglutide for weight loss is still being studied, and there is limited data on its effects over extended periods.
  • Injection-Based: Unlike some weight loss medications that come in pill form, semaglutide is administered through weekly injections, which may be a deterrent for some people.
  • Potential for Rebound Weight Gain: There is a risk of regaining weight once the treatment is discontinued.
  • Prescription Requirement: Semaglutide is only available via prescription, and it requires regular medical consultations and a doctor’s supervision.

Who’s a Good Candidate for Weight Loss Medication?

A good candidate for semaglutide for weight loss will meet the following criteria:

  • Can demonstrate a need to lose weight
  • Is committed to making healthy lifestyle changes
  • Does not have any contraindicating conditions (such as pancreatitis, thyroid cancer, or severe gastrointestinal issues) or an allergy to any of the ingredients in semaglutide
  • Has realistic expectations about semaglutide treatment

How Long Do You Stay on Semaglutide for Weight Loss?

The duration of time a person stays on semaglutide for weight loss can vary depending on their individual goals and response to the medication. Generally, healthcare providers recommend continuing the treatment as long as you’re experiencing significant weight loss. It’s not uncommon for people to be on semaglutide for up to two years. Ultimately, you and your doctor will decide how long you stay on semaglutide for weight loss.

How Much Can You Lose on Semaglutide in Three Months?

When taking semaglutide for weight loss, you can expect to see significant results within three months. Clinical trials indicate patients using semaglutide lose about 6% of their body weight after three months and 11% after six months.

That said, the exact amount of weight you’ll lose over the course of any given three months on semaglutide will depend on factors such as your dosage, adherence to the medication, dietary habits, and physical activity levels.

Is Semaglutide Worth It for Weight Loss?

Clinical trials have demonstrated that patients using semaglutide can lose a substantial amount of weight. However, the medication is not without its drawbacks. Its side effects can affect patients’ quality of life, and its cost can be prohibitive. Ultimately, the decision as to whether you should use semaglutide for weight loss should be made in consultation with a healthcare provider.


In conclusion, semaglutide presents a promising option for those struggling with weight loss. However, it’s essential to consider its drawbacks, including its side effects, cost, and questions about its long-term safety. Discussing your options with your doctor will ensure you make an informed decision that aligns with your needs and goals.

If you’ve struggled to lose weight through diet and exercise alone, semaglutide could be the answer. By enrolling in the Sanctuary Wellness Institute’s online medical weight loss program, you’ll gain access to semaglutide injections and ongoing support from a licensed physician. Book an evaluation today to find out whether you’re eligible.

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