How to Inject Testosterone
Testosterone injections are a widely used and effective method for treating low testosterone (Low T). These injections are typically administered intramuscularly (IM), which means the hormone is delivered directly into a muscle for reliable absorption and stable release into the bloodstream. Following your provider’s dosage instructions and administration guidance is essential for safe and effective Testosterone Replacement Therapy (TRT). MedlinePlus2
Preferred Injection Sites
The most common injection site for testosterone is the gluteal muscle (buttocks), which provides a deep and well-vascularized area ideal for hormone absorption. Some patients may use alternative sites such as the thigh (vastus lateralis) or the shoulder (deltoid muscle), depending on comfort, mobility, and provider recommendations. Rotating sites helps reduce soreness and maintain tissue health. Wexner Medical Center (Ohio State University)1
Needle Size and Selection
The appropriate needle size for testosterone injections typically ranges from 1.25 to 1.5 inches in length and between 19 and 25 gauge. The thickness (viscosity) of the testosterone solution, along with your provider’s recommendation, determines the best gauge for safe and comfortable administration. Mayo Clinic3
Safety, Technique, and Medication Handling
To ensure safe and effective therapy, always follow your healthcare provider’s instructions for injection technique, site rotation, and dose timing. Testosterone should not be refrigerated or frozen, as extreme temperatures may affect its stability. Used needles and syringes must be disposed of in a proper sharps container to maintain safety and prevent contamination.
- Follow your provider’s technique and site-rotation instructions.
- Store testosterone at room temperature—avoid freezing or extreme heat.
- Dispose of needles properly in a sharps container.
Proper injection technique, safe handling, and consistent dosing play an important role in ensuring that Testosterone Replacement Therapy remains comfortable, effective, and aligned with your treatment plan under medical supervision.
Important Disclaimer
The information provided here is for educational purposes only and should not be considered medical advice. Testosterone Replacement Therapy (TRT) dosage and treatment must be personalized and supervised by a licensed healthcare professional.
Do not begin, change, or discontinue any hormone therapy without consulting your provider. For medical guidance specific to your health and hormone needs, please schedule an evaluation with a qualified practitioner.