Causes of Low Testosterone in Men

Low testosterone (Low T) can develop due to a combination of age-related hormonal changes, underlying health conditions, and lifestyle influences. Testosterone naturally declines as men age, and research shows that a significant percentage of older men experience clinically low levels. These changes can impact energy, mood, sexual health, metabolism, and overall well-being. European Journal of Endocrinology³

Common Factors That Contribute to Low Testosterone

While aging is the most well-known factor, testosterone deficiency often results from several overlapping influences. Many men experience a combination of metabolic, medical, and lifestyle-related causes.

• Chronic health conditions — Disorders such as obesity, diabetes, metabolic syndrome, and chronic inflammation can impair hormone signaling and reduce testosterone production.
• Medications and medical treatments — Chemotherapy, corticosteroids, opioid medications, and long-term illness can suppress testosterone levels by affecting hormone pathways.
• Lifestyle influences — Poor nutrition, low physical activity, excessive alcohol consumption, and inadequate sleep have all been linked to reduced testosterone production and hormonal imbalance.
• High stress levels — Persistent stress elevates cortisol, which can interfere with healthy testosterone synthesis and disrupt the endocrine system.

These factors often compound one another—meaning that addressing the root cause may require a combination of medical evaluation and lifestyle modification rather than focusing on a single issue. Frontiers in Endocrinology²

Why Proper Evaluation Matters

Because low testosterone can arise from many different causes, a thorough medical assessment—including blood work, symptom review, and evaluation of underlying health factors—is essential before considering any form of treatment. This ensures the cause is accurately identified and the most appropriate therapy is recommended.

When clinically appropriate, Testosterone Replacement Therapy (TRT) can restore hormone balance, reduce symptoms, and improve long-term quality of life. TRT should always be prescribed and monitored by a qualified healthcare professional to ensure safety, correct dosing, and the best possible outcomes.

American College of Physicians¹

Important Disclaimer

The information provided here is for educational purposes only and should not be considered medical advice. Testosterone Replacement Therapy (TRT) must be personalized and supervised by a licensed healthcare professional.

Do not begin, change, or discontinue any hormone therapy without consulting your provider. Always seek guidance from a qualified practitioner for recommendations specific to your health needs.

1. American College of Physicians (ACP) – Guideline for testosterone treatment in adult men with age-related low testosterone
2. Frontiers in Endocrinology – Cross-sectional study of testosterone deficiency and systemic inflammation in aging men
3. European Journal of Endocrinology – Hypogonadism and metabolic health in men