Sanctuary Wellness Institute

Psilocybin Half Life

Psilocybin Half-Life


Psilocybin is a psychedelic compound found in some mushrooms.¬†As one of the four alkaloids found in magic mushrooms, psilocybin is responsible for the mushroom’s hallucinogenic effects. Psilocybin has been researched extensively for its potential therapeutic effects for those with mental conditions including anxiety, depression, obsessive-compulsive disorder (OCD), alcoholism, and cluster headaches.

Many of those who have ingested psilocybin claim to have experienced profound spiritual insights that allowed them to find themselves and their faith again. Research into psilocybin has suggested few cases of addiction formation and minimal side effects when taken responsibly in small doses and under specialized supervision.

Read on to learn more about how long the effects of psilocybin can last.

Psilocybin Half-Life

Psilocybin’s half-life is about 2.5 hours. This means that it takes about 2.5 hours for the drug’s presence to be reduced by half within your system.

How Long Do the Effects of Psilocybin Last?

The effects of psilocybin generally last about 6 hours. However, the intensity of the experience can vary widely depending on the subject.

Side Effects

There are a few side effects associated with psilocybin, but they’re usually mild. They can include headaches, nausea, and dizziness. In rare cases, more serious side effects such as anxiety, paranoia, and hallucinations can occur.

It is important to be aware of these side effects before taking psilocybin and to take the drug in a safe and controlled environment.

Precautions When Taking Psilocybin

When taking psilocybin, it is important to be aware of the drug’s half-life. This means that you should thoughtfully consider any near-term plans that you might have that would require your full attention before ingesting psilocybin, as the drug can linger in your system for some time after consumption.

Additionally, it is important to take into account that psilocybin can have strong effects on your mood and mental state. Therefore, users should avoid driving or operating heavy machinery while under the influence of the drug. Additionally, it is advised not to mix psilocybin with other drugs or medications since that can have unpredictable effects.

Is it Safe to Take More Than One Dose?

No, it is not safe to take more than one dose in a single day. Psilocybin can be toxic if taken in high doses and can also cause adverse effects like nausea, vomiting, and anxiety. It is important to follow your provider’s recommended dosage to minimize such risks.

Can You Overdose on Psilocybin?

No, you cannot overdose on psilocybin. However, it is possible to have an adverse reaction to its use. Some potential reactions include confusion, anxiety, panic attacks, and paranoia. It is also possible to experience a “bad trip,” which can be a very unpleasant experience.

Where Can I Buy Psilocybin?

You can purchase psilocybin online from a variety of different retailers, but it is important to do your research to ensure you are buying from a reputable source. You should never purchase psilocybin without a prescription from a doctor or pharmacist since it may be illegal in your country.


Psilocybin, the psychoactive compound found in magic mushrooms, has a half-life of around 2.5 hours. This means that after 2.5 hours, only half of the psilocybin will remain in your system. For this reason, it is recommended that you do not take another dose for at least 12 hours after your first one to avoid any adverse effects.

Psilocybin is metabolized by the body into psilocin, which is responsible for its psychedelic effects. Psilocin is eliminated from the body relatively quickly, so it is important to wait long enough between doses to allow it to be fully metabolized before taking more.

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