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Metformin vs. Semaglutide

Metformin vs. Semaglutide
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In the realm of diabetes management and weight loss, metformin and semaglutide represent two of the most popular medications on the market. Both have demonstrated an ability to regulate blood sugar levels, aid in weight loss, and offer additional health benefits. In this article, we’ll explore the similarities and differences between the two drugs to help you decide which is best for you.

What Is Semaglutide and What Is it Used For?

Semaglutide is a medication that belongs to a class of drugs known as GLP-1 receptor agonists. It functions by mimicking the GLP-1 hormone to lower blood sugar levels, suppress appetite, and slow gastric emptying.

Semaglutide was originally designed for the treatment of type 2 diabetes, but it’s also used to help patients lose weight in conjunction with a balanced diet and regular physical activity.

What Is Metformin and What Is it Used For?

Metformin is a medication that belongs to a class of drugs known as biguanides, which are used primarily in the treatment of type 2 diabetes. It works by lowering the amount of sugar your liver produces and your intestines absorb, thereby restoring your body’s proper response to insulin.

Metformin has also been shown to help diabetes patients lose excess weight.

Differences Between Ozempic and Metformin

What Are the Differences Between Ozempic and Metformin?

Some of the primary differences between Ozempic and metformin include:


  • Ozempic promotes weight loss by slowing gastric emptying and reducing appetite.
  • Metformin contributes to weight loss by decreasing glucose production and helping your body use its own insulin more effectively.


  • Ozempic is administered via a weekly subcutaneous injection.
  • Metformin is taken orally, usually in the form of a tablet, once or twice a day.


  • Some of the more rare but severe risks of Ozempic include pancreatitis, gallbladder disease, and thyroid tumors.
  • Rare but serious risks of taking metformin include lactic acidosis and flu-like symptoms.

Cost and Availability

  • Ozempic requires a prescription from a healthcare professional and is generally more expensive than metformin.
  • Metformin is available both by prescription and over the counter as a low-cost generic drug.

Is Metformin as Effective as Semaglutide for Weight Loss?

Semaglutide is significantly more effective than metformin for weight loss. Studies have proven that semaglutide can generate substantial weight loss for individuals with or without diabetes, while the weight loss observed with metformin is usually minimal and considered an incidental benefit.

Metformin may contribute to slight weight loss in some individuals, but semaglutide is specifically designed and approved for more significant weight loss.

Can I Switch Between Ozempic and Metformin?

The answer as to whether you can safely switch between Ozempic and metformin will depend on your current blood sugar levels and drug regimen. Always follow your doctor’s recommendation.

Is it Safe to Use Ozempic and Metformin Together?

Current medical guidelines suggest that using Ozempic and metformin together is safe. However, it’s crucial to understand that outcomes can vary between patients. For this reason, these medications should only be combined under the guidance of a healthcare professional.


In conclusion, both metformin and semaglutide represent effective options for managing type 2 diabetes and losing weight, but they function through different mechanisms and carry different side effects. Semaglutide has proven to be more effective for weight loss, while metformin is a more accessible and cost-effective option that can provide more health benefits. The choice between metformin and semaglutide should be made based on your individual needs, medical history, and doctor’s guidance.

If you’re interested in using weight loss injections to lose weight, the Sanctuary Wellness Institute can help. Members of our medical weight loss program get their medication delivered straight to their homes and enjoy ongoing support from a licensed physician and our care team. Book an evaluation today to discover whether you’re eligible for medical weight loss injections.

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