What Is Compounded Semaglutide?

Compounded semaglutide is a customized formulation of the medication semaglutide, prepared by a licensed compounding pharmacy. Semaglutide itself is an FDA-approved active ingredient originally developed to help manage type 2 diabetes and, more recently, has been widely recognized for its effectiveness in supporting medical weight management. It works by mimicking a natural hormone in the body ( GLP-1, or glucagon-like peptide-1), which helps regulate blood sugar, slow digestion, reduce appetite, and promote a feeling of fullness. Healthgrades¹

Compounded medications must be tested for potency, sterility, and purity.

How Compounded Semaglutide Differs from Brand-Name Versions

Brand-name medications contain semaglutide in FDA-approved formulations and doses. However, due to supply shortages, accessibility issues, or the need for personalized dosing, some patients may receive semaglutide through a compounding pharmacy. PMC / NCBI²

• Compounded versions are not mass-produced; instead, they are tailored in smaller batches based on a healthcare provider’s prescription.
• They may be formulated in different delivery methods (such as injectable solutions or oral capsules) depending on patient needs.
• Unlike the FDA-approved brand products, compounded semaglutide does not go through the same large-scale FDA approval process, but compounding pharmacies must still follow strict safety and quality standards.

Important Disclaimer

The information provided here is for educational purposes only and should not be interpreted as medical advice. GLP-1 medication dosing, indications, and treatment plans must be individualized and managed under the supervision of a licensed healthcare professional.

Do not start, adjust, or discontinue any GLP-1 therapy without consulting your healthcare provider. For guidance specific to your metabolic health, weight management goals, and medication needs, please schedule an evaluation with a qualified practitioner.

1. Healthgrades — How Does Semaglutide Work? (Weight Control & Obesity)
2. PMC / NCBI — Clinical Study: Semaglutide’s Effects on Weight Management