GLP-1 Agonist Medications | The Sanctuary Wellness Institute

GLP-1 (glucagon-like peptide-1) agonists were originally developed to help control blood sugar levels in people with type 2 diabetes. However, these medications have gained widespread recognition for their effectiveness in promoting weight loss, reducing inflammation, and even assisting with conditions like addiction and neurodegenerative diseases.

Some common GLP-1 medications include brand names such as Ozempic, Wegovy, and Trulicity. In this article, we’ll explore how GLP-1 drugs work in the body, how they support weight loss, manage addiction, reduce inflammation, and more.

How GLP-1 Medication Works

GLP-1 agonists are a class of medications that mimic the effects of the GLP-1 hormone, which is naturally produced in the gut after eating. This hormone’s primary role is to regulate blood sugar by stimulating the release of insulin from the pancreas while simultaneously suppressing glucagon, another hormone that raises blood sugar.

GLP-1 medications accomplish the following:

Prevents blood sugar spikes after meals, which is particularly beneficial for individuals with diabetes.
Regulates areas of the brain responsible for satiety, hunger, and reward. When GLP-1 levels increase, individuals tend to feel full sooner and for a longer duration.
Delays gastric emptying, meaning that food remains in the stomach longer, which helps reduce hunger and calorie intake.

Who Should Use GLP-1 Agonists

GLP-1 agonists, such as semaglutide, are prescription medications primarily intended for individuals with specific health needs related to weight management and blood sugar control.

These medications are often prescribed to people with type 2 diabetes to help manage blood glucose levels and reduce the risk of cardiovascular issues. However, they are also used as weight management tools in individuals who are overweight, especially those with related health conditions like high blood pressure, high cholesterol, or sleep apnea.

People who may benefit from GLP-1 agonists include:

Individuals with Type 2 Diabetes: GLP-1 agonists help regulate blood sugar by enhancing insulin release, reducing glucagon levels, and slowing gastric emptying, which can aid in better glycemic control.
Overweight Adults with Health Conditions: Individuals carrying excess weight, especially with related health issues like high blood pressure or sleep apnea, may benefit from GLP-1 agonists to support weight loss and improve metabolic health.
People Struggling with Weight Loss through Lifestyle Changes Alone: For some, diet and exercise may not be sufficient to achieve significant weight loss. GLP-1 agonists can serve as a supportive tool alongside lifestyle modifications.

How to Get a Prescription for GLP-1 Medications

In order to obtain a prescription for GLP-1 medications, you will need to book an appointment with a physician and fill out a brief form detailing your medical history and goals while using the medication.

Next you can meet with the doctor either in person or via telehealth, where you will go over your medical history together and discuss how you hope to benefit while using this medication. If you are deemed a suitable candidate for GLP-1 medication, the physician will issue a lab order for blood work.

At The Sanctuary Wellness Institute, our patients have the convenience of administering GLP-1 medication right from home, which is why once the prescription is shipped from the pharmacy, you can schedule a follow-up appointment to learn how to self-administer GLP-1 medication. This instructional visit is provided at no additional charge.

How to Take GLP-1

GLP-1 agonists are available in different forms, including injections and pills, with varying dosing schedules depending on the specific medication.

Injections: Most GLP-1 agonists are available as injectables, typically administered with a syringe. These injections are usually self-administered in areas such as the abdomen, thigh, or upper arm. Some formulations require daily injections, while others are designed for weekly dosing, providing a convenient option for those who prefer less frequent administration.
Oral Tablets: A few GLP-1 agonists are available as daily oral tablets, offering an option for those who prefer not to use injections. These tablets should be taken on an empty stomach, often with specific instructions about timing relative to meals to ensure optimal absorption.

Your healthcare provider will determine the best form and dosage schedule based on your health needs, lifestyle, and personal preferences.

Side Effects & Risks of GLP-1 Medication

GLP-1 medications are effective for weight loss and blood sugar management, but they can also cause side effects. Common side effects include nausea, vomiting, diarrhea, constipation, and decreased appetite. These symptoms often improve as the body adjusts to the medication, but if they persist, it’s essential to consult with a healthcare provider.

In rare cases, GLP-1 medications may lead to more serious risks, such as pancreatitis, gallbladder issues, or kidney problems. There’s also a potential increased risk of thyroid tumors, particularly for those with a family history of certain thyroid cancers.

Additionally, GLP-1 medications are not recommended for individuals with a personal or family history of medullary thyroid carcinoma or multiple endocrine neoplasia syndrome type 2.

It’s crucial to discuss all potential side effects and risks with your healthcare provider to ensure that GLP-1 medication is a safe option based on your medical history and health goals.

Are GLP-1 Agonists FDA-approved?

Yes, GLP-1 agonists are FDA-approved for specific uses, though the approval may vary depending on the condition being treated.

For Type 2 Diabetes: GLP-1 agonists are FDA-approved as a treatment for type 2 diabetes. They help manage blood sugar levels by increasing insulin production, decreasing glucagon release, and slowing gastric emptying.
For Overweight Individuals: Certain GLP-1 agonists are also FDA-approved for weight management in individuals who are overweight with related health conditions, such as high blood pressure or diabetes. These medications support weight loss by reducing appetite and improving metabolic function.

However, while GLP-1 agonists are widely prescribed for these purposes, they may not be FDA-approved for off-label uses, such as for other forms of weight loss or conditions not specified in their approval. It is important to discuss with your healthcare provider whether a GLP-1 agonist is an appropriate treatment for your specific needs.

GLP-1 and Weight Loss

Weight loss is one of the most popular off-label uses for GLP-1 medications. By influencing satiety centers in the brain, GLP-1 medications like Ozempic reduce the urge to overeat, leading to a natural decrease in calorie consumption without extreme diet restrictions.

Additionally, by delaying gastric emptying, GLP-1 medications make individuals feel fuller for longer. This can prevent unnecessary snacking and overeating, which are common obstacles in weight loss efforts.

Finally, GLP-1 drugs appear to reduce cravings for high-calorie, sugary, or fatty foods, making it easier to stick to a balanced diet. Patients often report a noticeable reduction in their desire for sweets and processed foods, which can be particularly beneficial for those struggling with emotional eating or food addiction.

For individuals facing weight-related health challenges, such as hypertension or metabolic syndrome, GLP-1 medications offer a dual benefit of supporting weight loss while improving blood sugar control.

The weight loss achieved through these medications has been shown to improve overall health markers, including reduced cholesterol levels and improved blood pressure, making GLP-1 an attractive option for individuals looking to enhance both their physical and metabolic health.

Other Potential Benefits of GLP-1 Agonists

Beyond blood sugar control and weight management, GLP-1 agonists are being studied for additional health benefits, such as:

Managing Addiction: GLP-1 receptors are located in regions of the brain associated with reward and addiction, such as the nucleus accumbens and the ventral tegmental area. GLP-1 medications can influence these brain regions to reduce the rewarding effects of addictive substances, which can help curb cravings and dependency.
Reducing Inflammation: Research suggests that GLP-1 medications may have anti-inflammatory properties, helping modulate immune responses and reduce chronic inflammation. By decreasing the production of inflammatory molecules, GLP-1 medications may reduce the risk of inflammation-related diseases and promote overall health.
Treating Alzheimer’s: GLP-1 drugs may have neuroprotective effects, helping prevent the buildup of harmful proteins associated with Alzheimer’s, such as beta-amyloid plaques and tau tangles. GLP-1 also helps reduce neuroinflammation, which is believed to play a role in Alzheimer’s progression.

Conclusion

Originally designed for type 2 diabetes management, GLP-1 agonists have shown promise as aids for weight loss and other conditions. GLP-1 medications are effective not only for managing diabetes but also for weight loss and other health benefits. With their expanding scope, GLP-1 agonists offer a multifaceted approach to treating complex health issues.

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