Sanctuary Wellness Institute
Close this search box.

Semaglutide for PCOS

Semaglutide for PCOS
Table of Contents

Patients suffering from Polycystic Ovary Syndrome (PCOS) don’t always achieve the relief they need from traditional treatment methods. Fortunately, recent studies have shed light on a treatment option that could do more to improve their quality of life: semaglutide. This medication could offer significant benefits for women struggling with PCOS, particularly with regard to weight management and metabolic health.

In this article, we’ll explore emerging evidence on the efficacy of semaglutide for PCOS and break down what it means for PCOS patients.

What Is PCOS and What Are the Symptoms?

PCOS is a condition that affects women of reproductive age that’s caused by an imbalance of reproductive hormones. Women with PCOS can have irregular or prolonged menstrual periods and elevated androgen levels. Their ovaries can also develop small fluid-filled sacs containing immature eggs called follicle cysts.

The symptoms of PCOS include:

  • Irregular periods or no periods at all
  • Hirsutism
  • Polycystic ovaries
  • Weight gain
  • Darkening of the skin (particularly in the folds of the neck, between the legs, and underneath the breasts)
  • Thinning hair
  • Infertility

Does Semaglutide Work for PCOS?

Semaglutide, which was originally approved for the treatment of type 2 diabetes and obesity, has demonstrated an ability to alleviate some symptoms of PCOS. Namely, the medication can improve PCOS patients’ insulin sensitivity, help them lose weight, and alleviate symptoms associated with high androgen levels like acne and excessive hair growth.

That said, research on semaglutide’s effectiveness for PCOS is ongoing, and you should speak to a doctor before using the medication.

Risks and Side Effects of Using Semaglutide for PCOS

What Are the Risks and Side Effects of Using Semaglutide for PCOS?

Like any medication, semaglutide carries risks and side effects. Patients considering using semaglutide for PCOS should keep the following ones in mind:

  • Gastrointestinal Issues: The most commonly reported side effects of semaglutide include nausea, vomiting, diarrhea, abdominal pain, and constipation. These symptoms are typically most pronounced during the initial phase of treatment and tend to subside over time.
  • Risk of Low Blood Sugar: Though less common in patients without diabetes, semaglutide can lead to hypoglycemia.
  • Thyroid Tumors: In animal studies, semaglutide has been linked to an increased risk of thyroid C-cell tumors. It’s unclear if this risk applies to humans.
  • Pancreatitis: There is a risk of developing pancreatitis while taking semaglutide.
  • Gallbladder Problems: Use of semaglutide may lead to gallbladder disorders, including gallstones and inflammation of the gallbladder.
  • Kidney Issues: Dehydration resulting from semaglutide’s gastrointestinal side effects can lead to kidney problems, including kidney failure.
  • Allergic Reactions: Though rare, some individuals may experience severe allergic reactions to semaglutide. Symptoms can include swelling of the face, lips, tongue, or throat, difficulty breathing, and severe rash or itching.

Can You Get Prescribed Semaglutide for PCOS?

You can’t get prescribed semaglutide for PCOS because the drug isn’t currently approved for PCOS by regulatory agencies. That said, some healthcare providers may prescribe it off-label for PCOS, especially if you’re struggling with insulin resistance, weight management, and/or metabolic complications due to PCOS.

It’s important to discuss the potential benefits and risks of semaglutide for PCOS with your doctor before trying to obtain the medication.

Does Insurance Cover Semaglutide for PCOS?

Since semaglutide is not FDA-approved for treating PCOS, you probably won’t be able to obtain insurance coverage for it unless you also have type 2 diabetes.

Contact your insurance provider to find out whether they cover semaglutide for PCOS.


In conclusion, semaglutide represents a promising treatment option for the symptoms of PCOS, especially for patients who struggle with weight management and insulin resistance. While the medication is not specifically approved for PCOS, emerging evidence suggests it may offer significant benefits. However, it’s crucial to talk to your doctor before using semaglutide for PCOS.

If you’re struggling to lose weight through diet and exercise, the Sanctuary Wellness Institute can help. Patients in our medical weight loss program self-administer weight loss injections and receive ongoing guidance from a physician and support from our care team. Book an evaluation today to find out whether you’re eligible.

How we reviewed this article: